Synthesis, Characterization and Antioxidant Studies of Quinazolin Derivatives
نویسنده
چکیده
3-((4-(dimethylamino)benzylidene)amino)-2-methylquinazolin-4(3H)-one (3), 3-((4hydroxybenzylidene)amino)-2-methylquinazolin-4(3H)-one (4), 2-methyl-3-(pyrrolidin-2-ylideneamino) quinazolin-4(3H)-one (5) and 3,3'-((1,4-phenylenebis(methanylylidene)) bis(azanylylidene))bis(2methylquinazolin-4(3H)-one) (6) derived from 3-amino-2-methylquinazolin-4(3H)-one have been synthesized and characterized by elemental analysis, FT-IR, NMR techniques and screened to establish their potential as antioxidants against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Nitric oxide (NO) radical scavengers. The results revealed that synthesized compounds (5 and 6) are much higher than common antioxidants ascorbic acid and they showed excellent scavenging capacity against DPPH and Nitric oxide (NO). The synthesized compounds (3 and 4) demonstrated encouraging results comparable with ascorbic acid.
منابع مشابه
Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
متن کاملSynthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
متن کاملSynthesis, Characterization and Antibacterial Activity Studies of Some N-Acyl-N'-aryl Thiourea Derivatives
Some N¬-acyl-N'-aryl thiourea derivatives 4(a-f) have been prepared by the reaction of acyl halides ammonium thiocyanate and aryl amines. The structures of synthesized compounds have been characterized by IR, 1HNMR spectral studies. The synthesized compounds 5(a-f) have been screened for antibacterial activity. The effect of the structure of the investigated compounds on the antibacterial activ...
متن کاملSynthesis and characterization of some polymer derivatives of carvacrol as drug delivery system
Carvacrol is one of the main components of the EO of some Labiatae (Laminaceae) members like oregano, thyme and savory. Carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.We synthesized some silicon derivatives of carvacrol, and characterized them by standard methods. Then the monomer of dimethylvinylsilyl carvacrol was synthesized. Copolymer of this mon...
متن کاملSynthesis, Antimicrobial and Electrochemical Studies of Four Substituted Isatin Derivatives at a Glassy Carbon Electrode
Isatins, derivatives of indole, represent important class of compounds belonging to nitrogen heterocycles. These compounds comprise synthetically vital substrates that are used as precursors for drug synthesis and raw materials for heterocycles etc. Research in this group of compounds has engrossed interest among scientific community in recent and past as Isatins are known to possess immense bi...
متن کامل